The nursing experience of long-term maintenance hemodialysis in a patient with rare and life-threatening calciphylaxis for more than 12 years was summarized. Nursing points include preoperative dietary care,implementation of an individualized hemodialysis nursing program,postoperative wound care,pain management,drug treatment,nutritional support,individualized calciphylaxis preventive care of end stage renal disease（ESRD） patients,etc. under the multidisciplinary approach. During the hospitalization,the patient underwent 2 operations,which lasted 25 days. The right upper limb recovered well and the patient was discharged. Dressing was regularly changed in wound stomy clinic and the wound healed completely.